Can I read Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma on EtoBox?
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma by Ren, L.; Ruiz-Rodado, V.; Dowdy, T.; Huang, S.; Issaq, S. H.; Beck, J.; Wang, H.; Tran Hoang, C.; Lita, A.; Larion, M.; LeBlanc, A. K. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma about?
## Background Osteosarcoma (OS) is a malignant bone tumor that often develops during the period of rapid growth associated with adolescence. Despite successful primary tumor control accompanied by adjuvant chemotherapy, death from pulmonary metastases occurs in approximately 30% of patients within 5 years. As overall survival in patients remains unchanged over the last 30 years, urgent needs for novel therapeutic strategies exist. Cancer metastasis is characterized by complex molecular events which result from alterations in gene and protein expression/function. Recent studies suggest that metabolic adaptations, or “metabolic reprogramming,” may similarly contribute to cancer metastasis. The goal of this study was to specifically interrogate the metabolic vulnerabilities of highly metastatic OS cell lines in a series of in vitro and in vivo experiments, in order to identify a tractable metabolically targeted therapeutic strategy for patients. ## Methods Nutrient deprivation and drug treatment experiments were performed in MG63.3, 143B, and K7M2 OS cell lines to identify the impact of glutaminase-1 (GLS1) inhibition and metformin treatment on cell proliferation. We functionally vali
Who reads Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ren, L.; Ruiz-Rodado, V.; Dowdy, T.; Huang, S.; Issaq, S. H.; Beck, J.; Wang, H.; Tran Hoang, C.; Lita, A.; Larion, M.; LeBlanc, A. K.
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2013-; Springer Science and Business Media LLC (ISSN 2049-3002)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)