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Macrophage Migration Inhibitory Factor Exhibits a Pronounced Circadian Rhythm Relevant to Its Role as a Glucocorticoid Counter-regulator by Petrovsky, Nikolai; Socha, Luis; Silva, Diego; Grossman, Ashley B; Metz, Christine; Bucala, Richard is a Immunology and Microbiology article available to read on EtoBox.
What is Macrophage Migration Inhibitory Factor Exhibits a Pronounced Circadian Rhythm Relevant to Its Role as a Glucocorticoid Counter-regulator about?
In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day‐time. The pro‐inflammatory cytokine, macrophage migration inhibitory factor counter‐regulates glucocorticoid‐mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal‐ and stimulated‐macrophage migration inhibitory factor. Similar to cortisol, macrophage migration inhibitory factor peaked during the late morning whereas interferon‐γ, tumour necrosis factor‐α, interleukin‐1 and interleukin‐12 demonstrated a nocturnal peak. After oral cortisone, plasma macrophage migration inhibitory factor rose 2–4‐fold, whereas the other cytokines decreased. There was no correlation between cortisol during the insulin tolerance test and plasma macrophage migration inhibitory factor. The late morning peak of macrophage migration inhibitory factor, by antagonizing cortisol‐mediated pro‐inflammatory cytokine suppression may prolong the duration of early morning inflammation. Thes
Who reads Macrophage Migration Inhibitory Factor Exhibits a Pronounced Circadian Rhythm Relevant to Its Role as a Glucocorticoid Counter-regulator?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Petrovsky, Nikolai; Socha, Luis; Silva, Diego; Grossman, Ashley B; Metz, Christine; Bucala, Richard
- Publisher
- Nature Publishing Group; Wiley (Blackwell Publishing); John Wiley and Sons Inc.; Wiley (ISSN 0818-9641)
- Published
- 2003
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)