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Can I read Mendelian Randomisation Study of the Effects of Known and Putative Risk Factors on Pancreatic Cancer on EtoBox?
Mendelian Randomisation Study of the Effects of Known and Putative Risk Factors on Pancreatic Cancer by Lu, Ye; Gentiluomo, Manuel; Lorenzo-Bermejo, Justo; Morelli, Luca; Obazee, Ofure; Campa, Daniele; Canzian, Federico is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mendelian Randomisation Study of the Effects of Known and Putative Risk Factors on Pancreatic Cancer about?
## Background Observational studies have reported multiple risk factors for pancreatic ductal adenocarcinoma (PDAC). Some are well established, like tobacco smoking, alcohol drinking, obesity and type 2 diabetes, whereas some others are putative, such as allergy and dietary factors. Identifying causal risk factors can help establishing those that can be targeted to contribute to prevent PDAC. ## Objective We sought to investigate the possible causal effects of established and putative factors on PDAC risk. ## Methods We conducted a two-sample Mendelian randomisation (MR) study using publicly available data for genetic variants associated with the factors of interest, and summary genetic data from genome-wide association studies of the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4), including in total 8769 cases and 7055 controls. Causality was assessed using inverse-variance weighted, MR-Egger regression and weighted median methods, complemented with sensitivity and radial MR analyses. ## Results We found evidence for a causal effect of body mass index (BMI) on PDAC risk (OR 1.43, 95% CI 1.20 to 1.71, p=8.43×10^−5^). Fasting
Who reads Mendelian Randomisation Study of the Effects of Known and Putative Risk Factors on Pancreatic Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lu, Ye; Gentiluomo, Manuel; Lorenzo-Bermejo, Justo; Morelli, Luca; Obazee, Ofure; Campa, Daniele; Canzian, Federico
- Publisher
- BMJ Publishing Group; BMJ (ISSN 0022-2593)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)