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Activation of P38 Mitogen-activated Protein Kinase in Spinal Hyperactive Microglia Contributes to Pain Hypersensitivity Following Peripheral Nerve Injury by Makoto Tsuda; Akito Mizokoshi; Yukari Shigemoto-Mogami; Schuichi Koizumi; Kazuhide Inoue is a Neuroscience article available to read on EtoBox.
What is Activation of P38 Mitogen-activated Protein Kinase in Spinal Hyperactive Microglia Contributes to Pain Hypersensitivity Following Peripheral Nerve Injury about?
## Abstract Neuropathic pain is an expression of pathological operation of the nervous system, which commonly results from nerve injury and is characterized by pain hypersensitivity to innocuous stimuli, a phenomenon known as tactile allodynia. The mechanisms by which nerve injury creates tactile allodynia have remained largely unknown. We report that the development of tactile allodynia following nerve injury requires activation of p38 mitogen‐activated protein kinase (p38MAPK), a member of the MAPK family, in spinal microglia. We found that immunofluorescence and protein levels of the dually phosphorylated active form of p38MAPK (phospho‐p38MAPK) were increased in the dorsal horn ipsilateral to spinal nerve injury. Interestingly, the phospho‐p38MAPK immunofluorescence in the dorsal horn was found exclusively in microglia, but not in neurons or astrocytes. The level of phospho‐p38MAPK immunofluorescence in individual microglial cells was much higher in the hyperactive phenotype in the ipsilateral dorsal horn than the resting one in the contralateral side. Intrathecal administration of the p38MAPK inhibitor, 4‐(4‐fluorophenyl)‐2‐(4‐methylsulfonylphenyl)‐5‐(4‐pyridyl)‐1H‐imidazole (
Who reads Activation of P38 Mitogen-activated Protein Kinase in Spinal Hyperactive Microglia Contributes to Pain Hypersensitivity Following Peripheral Nerve Injury?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Makoto Tsuda; Akito Mizokoshi; Yukari Shigemoto-Mogami; Schuichi Koizumi; Kazuhide Inoue
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)