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Topical Nifedipine^®^ for conservative treatment of acute haemorrhoidal thrombosis by Perrotti; Antropoli; Noschese; Bartone; Mo De Stefano; Pacifico; Maffettone; Antropoli is a Medicine article available to read on EtoBox.

What is Topical Nifedipine^®^ for conservative treatment of acute haemorrhoidal thrombosis about?

## Objective The aim of this prospective, randomized trial was to test the efficacy of the local application of Nifedipine gel^®^ in healing acute thrombosed haemorrhoids by relaxing the internal anal sphincter. ## Patients and methods Ninety patients who gave written informed consent were recruited; they received a clinical examination, anoscopy and a questionnaire to evaluate symptoms, pain and concurrent use of analgesics. Patients treated with Nifedipine (__n__=46) received topical 0.3% Nifedipine and 1.5% lidocaine gel every 12 h for 2 weeks. The control group, consisting of 44 patients, received topical 1.5% lidocaine and 1% hydrocortisone acetate gel during therapy. ## Results The results were as follows: relief of pain in 84.7% in Nifedipine group as opposed to 50% of controls after 7 days of therapy (__P__< 0.01); oral analgesics were used by 8.6% of patients in the Nifedipine group as opposed to 54.5% of the control group (__P__< 0.01); resolution of thrombosed haemorrhoids occurred after 14 days of therapy in 91.3% of the Nifedipine‐treated patients, as opposed to 45.4% of the controls (__P__< 0.01). No systemic side effects or significant anorectal bleeding were observe

Who reads Topical Nifedipine^®^ for conservative treatment of acute haemorrhoidal thrombosis?

Author

Perrotti; Antropoli; Noschese; Bartone; Mo De Stefano; Pacifico; Maffettone; Antropoli

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1462-8910)

Published

2000

Language

EN

Field

Medicine (Health Sciences)