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(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant Chromoplasts by Wenyun Gao; Reik Loeser; Maja Raschke; Marco A. Dessoy; Michael Fulhorst; Henriette Alpermann; Ludger A. Wessjohann; Meinhart H. Zenk is a Chemistry article available to read on EtoBox.

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Nature×s terpenoids, with over 35 000 known members, constitute compounds that are either essential for life (namely, cholesterol, vitamins) or represent secondary products, such as chemical attractants, defense compounds, and antibiotics. Until recently, terpenoids were assumed to be formed exclusively by the mevalonate pathway. [1] It has now been shown that an alternative metabolic route exists in plastids of higher plants and in the majority of bacteria. This pathway leads from pyruvate (1) and d-glyceraldehyde-3phosphate (2) via 1-deoxy-d-xylulose phosphate (3, DXP, Scheme 1) and the intermediates 4 ± 7 to the key metabolites isopentenyl diphosphate (9, IPP) and dimethylallyl diphosphate (10, DMAPP), which are essential to all organisms. [2] The cyclic diphosphate 7 has been proven to be a precursor to 9 and 10 in the alternative pathway and thus to plastidic isoprenoids, mainly phytoene (11). [3] This reaction involves a threefold, possibly stepwise, dehydroxylation at carbon atoms C-2, C-3, and C-4 of 7. On comparative phytochemical grounds, we postulated that (E)-4-hydroxy-3-methylbut-2-enyl diphosphate (8, Schemes 1 and 2) is a likely intermediate in the deoxyxylulose phos

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Author

Wenyun Gao; Reik Loeser; Maja Raschke; Marco A. Dessoy; Michael Fulhorst; Henriette Alpermann; Ludger A. Wessjohann; Meinhart H. Zenk

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 0044-8249)

Published

2002

Language

EN

Field

Chemistry (Physical Sciences)