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Identification of Heteroarylenamines as a New Class of Antituberculosis Lead Molecules by Brent R. Copp; Holly C. Christiansen; Brent S. Lindsay; Scott G. Franzblau is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Identification of Heteroarylenamines as a New Class of Antituberculosis Lead Molecules about?

Enamine-containing analogues of heteroarylquinones were prepared based on initial screening data observed against Mycobacterium tuberculosis H37Rv (Mtb). Several analogues showed moderate to good inhibitory activity, with one analogue (7) also demonstrating acceptable toxic selectivity (MIC 0.39 microg/mL, SI 15). Activity towards a range of single-drug-resistant strains of Mtb was suggestive of a novel mechanism of action for 7.

Who reads Identification of Heteroarylenamines as a New Class of Antituberculosis Lead Molecules?

Author

Brent R. Copp; Holly C. Christiansen; Brent S. Lindsay; Scott G. Franzblau

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)