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The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: a meta-analysis by H. L.-Y. Chan; J.-L. Tang; W. Tam; J. J.-Y. Sung is a Medicine article available to read on EtoBox.

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## Background: Trials of thymosin treatment in chronic hepatitis B virus infection have been small and the results have been inconsistent. ## Aim: To conduct a meta‐analysis to evaluate the efficacy of thymosin treatment in chronic hepatitis B virus infection. ## Methods: Randomized controlled trials comparing thymosin for over 24 weeks vs. placebo (or usual care) in the treatment of chronic hepatitis B virus infection were identified through MEDLINE, EMBASE and the Cochrane Register of Clinical Trials. Biochemical (normalization of transaminases) and virological (loss of hepatitis B virus DNA and hepatitis B e antigen) responses were analysed using the intention‐to‐treat method. The odds ratio was used to measure the magnitude of the efficacy. ## Results: Five trials (353 patients) were identified. The odds ratio (95% confidence interval) of the virological response of thymosin over placebo at the end of treatment, 6 months post‐treatment and 12 months post‐treatment were 0.56 (0.2–1.52), 1.67 (0.83–3.37) and 2.67 (1.25–5.68), respectively. There was an increasing trend of the virological response with time since the cessation of thymosin treatment (__P__=0.02). There was no diffe

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Author

H. L.-Y. Chan; J.-L. Tang; W. Tam; J. J.-Y. Sung

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)