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Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis by Meijun He; Qun Wang; Da Yao; Jing Li; Guang Bai is a Medicine article available to read on EtoBox.

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## Background/Aims The incidence of gastroesophageal reflux disease (GERD) is increasing annually. Studies have suggested that psychosocial disorders may be linked to the development of GERD. However, studies evaluating the association between psychosocial disorders and GERD have been inconsistent. Thus, we conducted a systematic review and meta-analysis of observational studies that evaluated the association between psychosocial disorders and GERD. ## Methods We systematically searched the PubMed, Embase, Cochrane, and Web of Science databases until October 17, 2020. Pooled OR with 95% CI and subgroup analyses were calculated using a random-effects model. Subgroup analyses were performed to identify the sources of heterogeneity. Sensitivity analysis by one-study removal was used to test the robustness of our results. ## Results This meta-analysis included 1 485 268 participants from 9 studies. Studies using psychosocial disorders as the outcome showed that patients with GERD had a higher incidence of psychosocial disorders compared to that in patients without GERD (OR, 2.57; 95% CI, 1.87-3.54; __I__^2^ = 93.8%; __P__ < 0.001). Studies using GERD as an outcome showed an association

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Author

Meijun He; Qun Wang; Da Yao; Jing Li; Guang Bai

Publisher

The Korean Society of Neurogastroenterology and Motility

Published

2022

Language

EN

Field

Medicine (Health Sciences)