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Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta‐analysis of randomized controlled clinical trials by Jamal Hallajzadeh; Alireza Milajerdi; Moein Mobini; Elaheh Amirani; Susan Azizi; Elhameh Nikkhah; Babak Bahadori; Razieh Sheikhsoleimani; Seyyed Mehdi Mirhashemi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The aim of this systematic review and meta‐analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I‐square (I^2^) statistic. Data were pooled using a random‐effects model and weighted mean difference (WMD) was considered as the overall effect size. A total of 50 trials were included in this meta‐analysis. We found a significant reduction in total cholesterol (WMD: −16.80; 95% CI: −21.04, −12.55), triglycerides (WMD: −15.73; 95% CI: −20.77, −10.69), LDL‐cholesterol (WMD: −18.45; 95% CI: −22.44, −14.94) and VLDL‐cholesterol (WMD: −3.72; 95% CI: −7.27, −0.18) following supplementation with N. sativa. In addition, there was significant reductive effect observed with N. sativa on fasting glucose (WMD: −15.18;

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Author

Jamal Hallajzadeh; Alireza Milajerdi; Moein Mobini; Elaheh Amirani; Susan Azizi; Elhameh Nikkhah; Babak Bahadori; Razieh Sheikhsoleimani; Seyyed Mehdi Mirhashemi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)