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Metabolism of fungicidal cyanooximes, cymoxanil and analogues in various strains of Botrytis cinerea by Frédérique Tellier; René Fritz; Lucien Kerhoas; Paul‐Henri Ducrot; Abel Carlin‐Sinclair; Jacques Einhorn; Pierre Leroux is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Metabolism of fungicidal cyanooximes, cymoxanil and analogues in various strains of Botrytis cinerea about?

## Abstract **BACKGROUND:** The metabolism of cymoxanil [1‐(2‐cyano‐2‐methoxyiminoacetyl)‐3‐ethylurea] and fungicidal cyanooxime analogues was monitored on three phenotypes of __Botrytis cinerea__ Pers. ex Fr. differing in their sensitivity towards cymoxanil. For this purpose, labelled [2‐^14^C]cymoxanil was added either to the culture medium of these strains or to its cell‐free extract. **RESULTS:** In the culture medium of the most sensitive strain, four main metabolites were detected. Three were isolated and identified. Cymoxanil was quickly metabolised by at least three concurrent enzymatic pathways: (i) cyclisation leading, after hydrolysis, to ethylparabanic acid, (ii) reduction giving demethoxylated cymoxanil, (iii) hydrolysis followed by reduction and then acetylation leading to __N__‐acetylcyanoglycine. In the cell‐free extract of the same strain, only the first and the second of these enzymatic reactions occurred. By comparing the metabolic profile of the most sensitive strain with that of the less sensitive ones, it was shown that the decrease in sensitivity to cymoxanil correlates with a reduced acetylcyanoglycine formation. Among all metabolites, only __N__‐acetylcyano

Who reads Metabolism of fungicidal cyanooximes, cymoxanil and analogues in various strains of Botrytis cinerea?

It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.

Author
Frédérique Tellier; René Fritz; Lucien Kerhoas; Paul‐Henri Ducrot; Abel Carlin‐Sinclair; Jacques Einhorn; Pierre Leroux
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-498X)
Published
2008
Language
EN
Field
Agricultural and Biological Sciences (Life Sciences)

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