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Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses by Susana López-Ortiz; Simone Lista; Pedro L. Valenzuela; José Pinto-Fraga; Ricardo Carmona; Filippo Caraci; Giuseppe Caruso; Nicola Toschi; Enzo Emanuele; Audrey Gabelle; Robert Nisticò; Francesco Garaci; Alejandro Lucia; Alejandro Santos-Lozano is a Medicine article available to read on EtoBox.
What is Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses about?
Introduction During the last decade, physical activity (PA) (or "exercise") has been identified as one of the main modifiable factors that influence the development of Alzheimer's disease (AD) pathophysiology. We performed an umbrella review to summarize the evidence on the association between PA/exercise and the risk of developing AD risk, and the effect of exercise interventions on the progression of AD. Methods A systematic search was performed in PubMed, SportDiscus, Cochrane Library and Web of Science (March 2022) to identify meta-analyses assessing the association between PA and the incidence of AD, and assessing the effect of exercise interventions on patients with AD. Results Twenty-one studies were included. The results with strongest evidence revealed the positive effects of PA on AD risk. Specifically, meeting the WHO recommendations for PA was associated with a lower risk of AD. They also revealed positive effects of exercise on cognitive function, physical performance, and functional independence. Conclusions There is strong evidence of a protective effect of regular PA against AD risk; however, the dose-response association remains unclear. Physical exercise seems to
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- Author
- Susana López-Ortiz; Simone Lista; Pedro L. Valenzuela; José Pinto-Fraga; Ricardo Carmona; Filippo Caraci; Giuseppe Caruso; Nicola Toschi; Enzo Emanuele; Audrey Gabelle; Robert Nisticò; Francesco Garaci; Alejandro Lucia; Alejandro Santos-Lozano
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)