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Longitudinal grey matter changes following first episode mania in bipolar I disorder: A systematic review by Ariana J. Cahn; Kamyar Keramatian; Christian Frysch; Lakshmi N. Yatham; Trisha Chakrabarty is a Psychology article available to read on EtoBox.

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## Background: While widespread grey matter (gm) changes are seen in bipolar i disorder (bd-i), it is unclear how early in the illness such changes emerge. to date there has been little synthesis of findings regarding longitudinal grey matter changes early in the course of bd-i. we conducted a systematic review to examine the evolution of gm changes in bd-i patients following the first episode of mania (fem). ## Methods: Following prisma guidelines, we conducted a systematic review of studies examining longitudinal changes in gm volume (gmv), cortical thickness and/or surface area in bd-i patients following fem. we qualitatively synthesized results regarding longitudinal gm changes in bd-i patients. ## Results: Fifteen studies met inclusion criteria, all examining gmv changes. longitudinal acc volume decrease following fem was the most replicated finding, but was only reported in 4 out of 7 studies that examined this region as part of a whole brain/region of interest analysis, with 2 of these positive studies using an overlapping patient sample. the impact of episode recurrence, medications, and other clinical factors was inconsistently examined. ## Limitations: The literature rega

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Author

Ariana J. Cahn; Kamyar Keramatian; Christian Frysch; Lakshmi N. Yatham; Trisha Chakrabarty

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Psychology (Social Sciences)