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Expression of epidermal growth factor in the rat kidney: An immunocytochemical and in situ hybridization study by E. C. Salido; J. Lakshmanan; D. A. Fisher; L. J. Shapiro; L. Barajas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Expression of epidermal growth factor in the rat kidney: An immunocytochemical and in situ hybridization study about?

The renal localization and the site of synthesis of epidermal growth factor (EGF) were investigated in the rat kidney by immunohistochemistry and in situ hybridization techniques. EGF was localized in the cells of the thick ascending limb of Henle (TAL) and distal convoluted tubule (DCT). At the ultrastructural level, EGF immunoreactivity was distributed on the apical membrane and trans-Golgi complex of the TAL and DCT cells. These segments of the rat nephron also hybridized to prepro-EGF cRNA probes in a specific manner, indicating that TAL and DCT are the sites of EGF synthesis in the rat kidney.

Who reads Expression of epidermal growth factor in the rat kidney: An immunocytochemical and in situ hybridization study?

Author

E. C. Salido; J. Lakshmanan; D. A. Fisher; L. J. Shapiro; L. Barajas

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

1990

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)