Opening book details…
Can I read Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations on EtoBox?
Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations by Yudibeth Sixto-López; Cynthia Ordaz-Pichardo; José Antonio Gómez-Vidal; Martha Cecilia Rosales-Hernández; José Correa-Basurto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations about?
Breast cancer (BC) is the leading cause of cancer-related death in women worldwide. Triple negative breast cancer (TNBC) is the most aggressive form of BC being with the worst prognosis and the worst survival rates. There is no specific pharmacological target for the treatment of TNBC; conventional therapy includes the use of non-specific chemotherapy that generally has a poor prognosis. Therefore, the search of effective therapies against to TNBC continues at both preclinical and clinical level. In this sense, the exploration of different pharmacological targets is a continue task that pave the way to epigenetic modulation using novel small molecules. Lately, the inhibition of histone deacetylases (HDACs) has been explored to treat different BC, including TNBC. HDACs remove the acetyl groups from the ɛ-amino lysine resides on histone and non-histone proteins. In particular, the inhibition of HDAC6 has been suggested to be useful for the treatment of TNBC due to it is overexpressed in TNBC. Therefore, in this work, an HDAC6 selective inhibitor, the (S)-4-butyl-N-(1-(hydroxyamino)-3-(naphthalen-1-yl)-1-oxopropan-2-yl) benzamide (YSL-109), was assayed on TNBC cell line (MDA-MB231) sh
Who reads Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yudibeth Sixto-López; Cynthia Ordaz-Pichardo; José Antonio Gómez-Vidal; Martha Cecilia Rosales-Hernández; José Correa-Basurto
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)