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Risk factors for malignancy in Japanese renal transplant recipients by Tetsuya Imao; Naotsugu Ichimaru; Shiro Takahara; Yukito Kokado; Masayoshi Okumi; Ryoichi Imamura; Yukiomi Namba; Yoshitaka Isaka; Norio Nonomura; Akihiko Okuyama is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND. Among recipients of renal transplants, the incidences of renal cancer and gastrointestinal cancer are higher and that of skin cancer is much lower in Japan than in Europe and North America. ## METHODS. The risk factors for the development of malignant tumors were examined in Japanese recipients of renal transplants. A total of 556 patients underwent renal transplantation at the Department of Urology, Osaka University Faculty of Medicine between March 1, 1965, and April 31, 2004. Of these patients, 366 were retrospectively studied in whom risk factors potentially related to the development of malignancy could be evaluated on the basis of medical records. The incidence of malignancy, survival rate, and risk factors for malignancy were examined. ## RESULTS. The overall incidence of malignancy was 6.8% (25/366 patients). Six of the 25 patients with malignancy died of cancer, but there was no correlation between the occurrence of malignancy and the survival rate (__P__ = .8058, log‐rank test). A Cox proportional‐hazards model identified treatment with tacrolimus (hazard ratio [HR] = 4.376; 95% confidence interval [CI]: 1.647–11.627; __P__ = .0031) and age at t

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Author

Tetsuya Imao; Naotsugu Ichimaru; Shiro Takahara; Yukito Kokado; Masayoshi Okumi; Ryoichi Imamura; Yukiomi Namba; Yoshitaka Isaka; Norio Nonomura; Akihiko Okuyama

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)