About this Medicine article
Clinical recurrence of hepatitis A following liver transplantation for acute liver failure by Edward Gane; Richard Sallie; Mohammed Saleh; Bernard Portmann; Prof. Roger Williams is a Medicine article available to read on EtoBox.
This paper documents clinically significant recurrence of hepatitis A virus (HAV) infection in a 63-year-old man transplanted for HAV-related acute liver failure. HAV RNA was documented in the explant and, following early clearance from the blood and graft, was again detected in postoperative biopsies at the time of an acute hepatic illness. Although the clinical and biochemical abnormalities resolved completely, the patient had a second episode of graft dysfunction 6 months later and investigations revealed hepatitis C virus (HCV)-related chronic active hepatitis consistent with acquired HCV infection at the time of transplantation. The possible interaction with hepatitis A may have delayed the appearance of hepatitis C. Administration of HAV immunoglobulin at the time of transplantation should be considered in all cases of HAV-related fulminant hepatic failure.
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- Author
- Edward Gane; Richard Sallie; Mohammed Saleh; Bernard Portmann; Prof. Roger Williams
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)