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Mouse fibroblasts that express a cloned gene for the human transferrin receptor induce a specific cytolytic T cell response by Janet L. Maryanski; Lukas C. Kühn; Giampietro Corradin is a Immunology and Microbiology article available to read on EtoBox.

What is Mouse fibroblasts that express a cloned gene for the human transferrin receptor induce a specific cytolytic T cell response about?

From CBA mice immunized with mouse L cells that express a cloned gene for the human transferrin receptor (hTR) we have isolated cytolytic T cells (CTL). The CTL were Lyt-2'/L3T4-and lysed L cell transfectant clones that expressed the hTR gene but not control untransfected L cells or transfectants selected for the expression of an unrelated human cell surface antigen, 4F2. Lysis of independent hTR transfectant clones correlated with the relative level of receptor expression. The availability of CTL directed against a non-major histocompatibility complex-controlled cellular protein-like hTR may provide an interesting model system for studying antigen processing and recognition.

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Author

Janet L. Maryanski; Lukas C. Kühn; Giampietro Corradin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1987

Language

EN

Field

Immunology and Microbiology (Life Sciences)