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In vivo Stability of Poly(ethylene glycol)-Collagen Composites by Woonza Rhee; Joel Rosenblatt; Marisol Castro; Jacqueline Schroeder; Prema R. Rao; Carol F. H. Harner; Richard A. Berg is a book available to read on EtoBox.

What is In vivo Stability of Poly(ethylene glycol)-Collagen Composites about?

Collagen materials were crosslinked by two different difunctional poly ethylene glycols (PEGs) for a variety of applications. Crosslinking was mediated by carbamation of primary amines on collagen with N-hydroxysuccinimide ester end-groups on the PEG crosslinkers. One crosslinker, disuccinimidyl glutarate PEG (di--SG-PEG), contained internal ester linkages which were capable of hydrolyzing and hence produced degradable networks. The other crosslinker, disuccinimidyl propionate PEG (di-SE-PEG), contained hydrolytically stable internal ether linkages and hence produced a more durable network. In vitro experiments verified that di-SE--PEG networks were more hydrolytically stable. In vivo experiments (rat subcutaneous model) revealed similar degradation rates for both networks indicating that other degradation mechanisms (probably enzymatic) also influence degradation in vivo. Histologic analysis revealed a mild inflammatory response to the implants accompanied by fibroblast ingrowth. A second in vivo study (bovine collagen hypersensitized guinea pigs), examined the immunogenicity of di--SG-PEG crosslinked materials and revealed that the PEG crosslinked implants showed lower antibody t

Author

Woonza Rhee; Joel Rosenblatt; Marisol Castro; Jacqueline Schroeder; Prema R. Rao; Carol F. H. Harner; Richard A. Berg

Publisher

An American Chemical Society Publication

Published

1997

Language

EN

ISBN

9780841216440

Subjects

Engineering, Mathematics, Science