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Handgrip Strength Predicts Survival and Is Associated with Markers of Clinical and Functional Outcomes in Advanced Cancer Patients by R. D. Kilgour; A. Vigano; B. Trutschnigg; E. Lucar; M. Borod; J. A. Morais is a Medicine article available to read on EtoBox.
What is Handgrip Strength Predicts Survival and Is Associated with Markers of Clinical and Functional Outcomes in Advanced Cancer Patients about?
Purpose Handgrip strength (HGS) has been shown to predict survival and is associated with changes in body composition, nutritional status, inflammation, and functional ability in several chronic disease conditions. Whether similar relationships exist between HGS and clinical outcomes in patients with advanced cancer are currently unknown. We evaluated the association between HGS and survival as well as several key markers of body composition (e.g., sarcopenia), subjective performance measures (e.g., quality of life), and muscle strength (e.g., isokinetic torque of the quadriceps) in patients with advanced forms of non-small cell lung and gastrointestinal cancers. Methods A consecutive cohort of 203 patients with advanced cancer was enrolled and categorized into three HGS percentiles (e.g., ≥50th, 25th, and ≤10th) according to published normative values. Multivariate regression analyses were used to test for independent associations between HGS and survival, sarcopenia, quality of life (QoL), and lower extremity muscle strength as well as key biological markers (e.g., hemoglobin, albumin, and C-reactive protein) while controlling for age, gender, cancer diagnosis, treatment (chemoth
Who reads Handgrip Strength Predicts Survival and Is Associated with Markers of Clinical and Functional Outcomes in Advanced Cancer Patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R. D. Kilgour; A. Vigano; B. Trutschnigg; E. Lucar; M. Borod; J. A. Morais
- Publisher
- Springer Science and Business Media LLC
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)
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