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Role of proton pump inhibitors in non-H. pylori-related ulcers by J.W. Freston is a Medicine article available to read on EtoBox.

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The proportion of ulcers that are not associated with __Helicobacter pylori__ infection is increasing, especially in the United States and Australia. The alarming increase in this type of ulcer warrants an analysis of the diagnostic and treatment approaches to __H. pylori__‐negative ulcers, which was the aim of this study. The medical literature was reviewed to gather information about the prevalence, aetiology, and treatment of __H. pylori__‐negative ulcers. The reports indicated that up to 52% of duodenal ulcers and 47% of gastric ulcers are not caused by __H. pylori__ infection. The cause of __H. pylori__‐negative ulceration appears to be multifactorial. Contributing factors include covert non‐steroidal anti‐inflammatory drug use, false‐negative __H. pylori__ tests, genetic predisposition, and in rare cases, Crohn’s disease or Zollinger–Ellison syndrome. __H. pylori__‐negative ulcers tend to be associated with hypersecretion and can have serious clinical sequelae. __H. pylori__‐negative ulcers are often refractory to treatment, possibly because they lack the beneficial effect of __H. pylori__ infection on antisecretory therapy. Proton pump inhibitors (PPIs) appear to effectively

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Author

J.W. Freston

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)