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## Progress in Basic Research of Wound Repair and its Application to Clinical Management of Problematic Wounds The Role of Inflarnmtion in Wound Reiiuir R 004 The inflammatory process is incomplete without the consequent repair of the tissue, optimally by restoration of normal structure and function, but all too often by fibrosis. Since inflammation is characterized by influx of migratory cells, alterations in vascular permeability and usually by local tissue damage the first step in repair has to involve removal of fluid, proteins, cells and cell debrisnot to mention any microorganisms or exogenous material that might have initiated the response. It is suggested that in the later phases of an acute inflammatory reaction, incoming monocytes mature along a number of different and mutually exclusive pathways to orchestrate these various reparative processes. 1. Phagocytosis of digestible particulate matter leads to expression of new surface receptors for phosphatidylserine as well as to increased synthesis of TGF-0, PDGF and lysosomal hydrolases by mechanisms that involve autocrine action of lipid mediators, TGF-O, PKC and perhaps engagement of surface integrins. The 1 5 receptors ar

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Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1993

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)