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Polio endgame complexity: updating expectations for nOPV2 by Kimberly M Thompson is a Medicine article available to read on EtoBox.

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In 2022, poliomyelitis cases caused by transmission of wild poliovirus type 1 and all three types (1, 2, and 3) of circulating vaccine-derived polioviruses (cVDPVs) were reported in 26 countries, with transmission detected without cases in eight additional countries. Notably, these cases included a type 2 cVDPV (cVDPV2) case in an unvaccinated 20-year-old in New York State, USA, 3 which provided a sobering reminder that all unvaccinated individuals remain at risk, even in countries that use only inactivated poliovirus vaccine and maintain very high average immunisation coverage. Similar to recent years, 5 polioviruses paralysed hundreds of African children in 2022 as countries chose to delay outbreak responses to wait for novel type 2 oral poliovirus vaccine (nOPV2), instead of preventing these cases using available Sabin monovalent type 2 oral poliovirus vaccine (mOPV2). Why wait? The accelerated development of nOPV2 came with many hopes, including non-inferior immunogenicity and greater genetic stability for nOPV2 compared with mOPV2, which promised similar individual and population immunity while reducing the risks of recombination and reversion to neurovirulence that might resu

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Author

Kimberly M Thompson

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)