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Can I read In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action on EtoBox?
In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action by Mannanthendil Kumaran Asha; Debnath Debraj; D'souza Prashanth; Jothie Richard Edwin; H.S. Srikanth; Nithyanantham Muruganantham; Shekhar Michael Dethe; Bhaskar Anirban; Balachandran Jaya; Mundkinajeddu Deepak; Amit Agarwal is a Agricultural and Biological Sciences article available to read on EtoBox.
What is In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action about?
## Ethnopharmacological relevance: Glycyrrhiza glabra linn. is regarded useful for peptic ulcer in traditional systems of medicine in india and helicobacter pylori has been considered as one of the causative factors for peptic ulcer. aim of the present study is to evaluate the anti-helicobacter pylori action of gutgard(®), a flavonoid rich extract of glycyrrhiza glabra and further to elucidate the possible mechanisms of its anti-helicobacter pylori action. ## Materials and methods: Agar dilution and microbroth dilution methods were used to determine the minimum inhibitory concentration of gutgard(®) against helicobacter pylori. protein synthesis, dna gyrase, dihydrofolate reductase assays and anti-adhesion assay in human gastric mucosal cell line were performed to understand the mechanisms of anti-helicobacter pylori activity of gutgard(®). ## Results: Gutgard(®) exhibited anti-helicobacter pylori activity in both agar dilution and microbroth dilution methods. glabridin, the major flavonoid present in gutgard(®) exhibited superior activity against helicobacter pylori while glycyrrhizin did not show activity even at 250 μg/ml concentration. in protein synthesis assay, gutgard(®) sho
Who reads In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Mannanthendil Kumaran Asha; Debnath Debraj; D'souza Prashanth; Jothie Richard Edwin; H.S. Srikanth; Nithyanantham Muruganantham; Shekhar Michael Dethe; Bhaskar Anirban; Balachandran Jaya; Mundkinajeddu Deepak; Amit Agarwal
- Publisher
- Elsevier BV
- Published
- 2013
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)