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Development of Parenteral Formulations and Evaluation of the Biological Activity of the Trypanocide Drug Benznidazole by María C. Lamas; Luciano Villaggi; Isabel Nocito; Georgina Bassani; Darío Leonardi; Fernanda Pascutti; Esteban Serra; Claudio J. Salomón is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Development of Parenteral Formulations and Evaluation of the Biological Activity of the Trypanocide Drug Benznidazole about?
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem in Latin America. According to the World Health Organization, around 20 million people are infected and another 40 million are at risk of acquiring the disease. One of the drugs most frequently used for the treatment of Chagas disease is benznidazole (BZL). It is practically insoluble in water (0.4 mg/ml), which precludes the preparation of liquid dosage forms, in particular, parenteral formulations. Thus, the aim of this work was to investigate the solubilization of BZL at two pH values using various cosolvents such as ethyl alcohol, propylene glycol, polyethylene glycol 400, benzyl alcohol, diethylene glycol monoethyl ether (Transcutol) and surfactants such as polysorbates (Tween) 40 and 80, and sodium dioctyl sulfosuccinate (AOT). Solvent systems based on PEG 400, with the addition ethyl alcohol and/or potassium biphthalate buffer solution, increased the BZL solubility up to 10 mg/ml. These alcoholic vehicles showed no toxicity against parasite when assayed at 1%. Physical and chemical stability studies showed that the formulations were stable for at least 1.5 years. In agreement with the biological ac
Who reads Development of Parenteral Formulations and Evaluation of the Biological Activity of the Trypanocide Drug Benznidazole?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- María C. Lamas; Luciano Villaggi; Isabel Nocito; Georgina Bassani; Darío Leonardi; Fernanda Pascutti; Esteban Serra; Claudio J. Salomón
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2006
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)