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Urease Inhibitors: Thiosemicarbazones Synthesis by Muhammad Islam is a document available to read on EtoBox.
The study presents the synthesis and biological evaluation of a series of N4-substituted thiosemicarbazones derived from 2-nitrocinnamaldehyde as potential urease inhibitors. The synthesized compounds exhibited significant urease inhibition with IC50 values ranging from 11.4 to 80.6 μM, with compound 3o showing the highest activity. Molecular docking studies indicated strong binding interactions with the urease active site, suggesting these compounds may serve as effective therapeutic agents against urease-
- Author
- Muhammad Islam
- Language
- EN