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Metalloproteinases 2 and 9 Are Increased in Plasma of Patients with Heart Failure by P. Altieri; C. Brunelli; S. Garibaldi; A. Nicolino; S. Ubaldi; P. Spallarossa; L. Olivotti; P. Rossettin; A. Barsotti; G. Ghigliotti is a Medicine article available to read on EtoBox.
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## Abstract **Background** Progression of heart failure is associated with interstitial changes in the heart and in areas distant from the heart. Enhanced expression of metalloproteinases 2 and 9 and of metalloproteinases tissue inhibitors 1 and 2 have been found in ventricular tissue of patients with heart failure. Our aim was to determine whether increased activity of metalloproteinase‐2, metalloproteinase‐9 and of metalloproteinases tissue inhibitor‐1 and metalloproteinases tissue inhibitor‐2 were also present in plasma of patients with heart failure. **Design** Levels of metalloproteinase‐2, metalloproteinase‐9 and of metalloproteinase tissue inhibitor‐1 and metalloproteinases tissue inhibitor‐2 were measured in venous blood of 51 patients with heart failure, and were compared with levels of 52 control subjects. Samples collected from patients and control subjects were assayed for gelatinolytic activity (zymography) and for protein levels. **Results** Compared with the control subjects, the patients with heart failure had a significant increase in activity levels (mean ± SE, ng mL^−1^) of prometalloproteinase‐9 (95·1 ± 11·2 and 38·9 ± 4·5^\*^), activ. metalloproteinase‐9 (18·4
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- Author
- P. Altieri; C. Brunelli; S. Garibaldi; A. Nicolino; S. Ubaldi; P. Spallarossa; L. Olivotti; P. Rossettin; A. Barsotti; G. Ghigliotti
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)