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Antiaddictive compound 18methoxycoronaridine has some antiaddiction activity in rats. Ibogaine (1) has been clinically used, but its stimulant and hallucinogenic activity excludes this alkaloid from consideration as a safe drug for the treatment of addiction to substance abuse. The best of our initial five coronaridine congeners,5a each with terminal oxygen substitution of the methoxycarbonyl, provided 15 congeners for SAR evaluation at opioid and R3b4

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Slapdragonx

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