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Can I read The Reaction of Carbonyl Cyanide Phenylhydrazones with Thiols on EtoBox?
The Reaction of Carbonyl Cyanide Phenylhydrazones with Thiols by L̆. Drobnica; E. Šturdík is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Reaction of Carbonyl Cyanide Phenylhydrazones with Thiols about?
Carbonyl cyanide phenylhydrazone and its ring-substituted analogs react with thiols (thioglycolic acid, 2-mercaptoethanol, dithiothreitol) and aminothiols (cysteine, glutathione) to give corresponding N-(substituted phenyl)-N'-(alkylthiodicyano)-methylhydrazine derivatives. These addition products decompose to the original components in alkaline solution. On the other hand, in the presence of an excess of thiols in aqueous buffered systems the addition reactions are practically quantitative with respect to phenylhydrazones, follow pseudo-first-order kinetics and can be investigated spectrophotometrically. These reactions are of the bimolecular AdN type where the non-dissociated form of carbonyl cyanide phenylhydrazones function as an electrophilic component, while the RS-ion plays the role of nucleophilic component in the case of thiols (the attack of the azomethine group). The reactivity of carbonyl cyanide phenylhydrazones with respect to thiols increases in the order carbonyl cyanide phenylhydrazone ~ carbonyl cyanide m-chlorophenylhydrazone ~ carbonyl cyanide p-trifluoromethoxyphenylhydrazone which corresponds to the order of decreasing values of the pK a constants. On the othe
Who reads The Reaction of Carbonyl Cyanide Phenylhydrazones with Thiols?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- L̆. Drobnica; E. Šturdík
- Publisher
- Elsevier BV
- Published
- 1979
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)