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Multiple System Aging‐related Tau Astrogliopathy with Complex Proteinopathy in an Oligosymptomatic Octogenarian by Sigrid Klotz; Peter Fischer; Margareta Hinterberger; Gerda Ricken; Selma Hönigschnabl; Ellen Gelpi; Gabor G. Kovacs is a Medicine article available to read on EtoBox.
What is Multiple System Aging‐related Tau Astrogliopathy with Complex Proteinopathy in an Oligosymptomatic Octogenarian about?
The combination of multiple neurodegenerative proteinopathies is increasingly recognized. Together they can potentiate neuronal dysfunction and contribute to complex neurological symptoms. We report an octogenarian female case of multiple extraneural metastases of a rectal carcinoma. She attempted suicide, which ultimately led to cardiorespiratory failure nine days after hospital admission. Apart from the suicide attempt and late‐onset depression, other psychiatric or neurological symptoms were not reported. Unexpectedly, histopathologic examination revealed prominent aging‐related tau astrogliopathy (ARTAG) of all five types (subpial, subependymal, grey and white matter, and perivascular) affecting cortical and subcortical brain regions. This pathology was associated with intermediate Alzheimer's disease neuropathologic change (A2B2C2 score), cerebral amyloid angiopathy, Lewy body‐type α‐synuclein proteinopathy (Braak stage 4), and a multiple system transactivation response DNA‐binding protein of 43 kDa (TDP‐43) proteinopathy also involving the astroglia. In summary, we report a complex and extensive combination of multiple proteinopathies with widespread ARTAG of all five types i
Who reads Multiple System Aging‐related Tau Astrogliopathy with Complex Proteinopathy in an Oligosymptomatic Octogenarian?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sigrid Klotz; Peter Fischer; Margareta Hinterberger; Gerda Ricken; Selma Hönigschnabl; Ellen Gelpi; Gabor G. Kovacs
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0919-6544)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)