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Can I read Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice on EtoBox?
Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice by Todd H. Rogers; Julia E. Babensee is a Engineering article available to read on EtoBox.
What is Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice about?
The host response to a biomaterial is characterized by both acute recruitment and attachment of cells as well as chronic encapsulating tissue reaction. The implantation procedure induces production of damage-associated molecular patterns (DAMPs) which may contribute to host recognition of the material. Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that bind not only pathogen-associated molecular patterns (PAMPs) but also DAMPs. We sought to investigate whether TLR4/DAMP interactions were involved in the acute and chronic inflammatory response to an implanted biomaterial. When PET discs were implanted intraperitoneally for 16h, no differences were found in the number of leukocytes recruited between TLR4(+) (C57BL/10J) and TLR4(-) (C57BL/10ScNJ) mice. However, a significant shift in the leukocyte profile on the biomaterial surface was observed for TLR4(-) mice. While the total number of adherent cells was the same in both strains, TLR4(+) mice had a profile with equivalent neutrophil and monocyte/macrophage presence on the material surface, and TLR4(-) mice had a profile of predominantly neutrophils with fewer monocyte/macrophages. When implants were placed subc
Who reads Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Todd H. Rogers; Julia E. Babensee
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2010
- Language
- EN
- Field
- Engineering (Physical Sciences)