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Biocompatibility and Cellular Uptake of Fluorescent Chitosan Nanohydrogels in Murine Macrophages and B Lymphocytes by Voicu, Sorina Nicoleta (author);Stan, Miruna-Silvia (author);Nica, Ionela Cristina (author);Balas, Mihaela (author);Moreau, Juliette (author);Cadiou, Cyril (author);Callewaert, Maïté (author);Chuburu, Françoise (author);Dinischiotu, Anca (author) is a nonfiction available to read on EtoBox.
What is Biocompatibility and Cellular Uptake of Fluorescent Chitosan Nanohydrogels in Murine Macrophages and B Lymphocytes about?
Due to their intrinsic viscosity and hydrophilicity, nanohydrogel systems are used to significantly increase the efficiency of commercial contrast agents for MRI and thus effectively improve the sensitivity of the MRI technique. Since chitosan (CS) is a biocompatible polysaccharide frequently used in biomedical applications, we aimed to prepare chitosan nanohydrogels (NGs) by ionic gelation, the polysaccharide being further grafted with rhodamine (RBITC) and fluorescein isothiocyanate (FITC). In this way, the cytotoxic effect of different concentrations (5, 15, 30, 60, and 120 μg/mL) of the fluorescent CS-FITC and CS-RBITC NGs was investigated by assessing the plasma membrane integrity and the metabolic activity of RAW 264.7 murine macrophages and A20 mouse lymphoma B cells following exposure for 6 and 24 h. The cell viability (MTT assay) and lactate dehydrogenase activity were analyzed by spectrophotometric methods, while cellular uptake was observed by fluorescence microscopy. Our results showed that the exposure to CS-FITC and CS-RBITC NGs for 6 and 24 h did not induce significant changes to RAW 264.7 and A20 cells compared to control, proving a good nanogel biocompatibility for
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- Author
- Voicu, Sorina Nicoleta (author);Stan, Miruna-Silvia (author);Nica, Ionela Cristina (author);Balas, Mihaela (author);Moreau, Juliette (author);Cadiou, Cyril (author);Callewaert, Maïté (author);Chuburu, Françoise (author);Dinischiotu, Anca (author)
- Publisher
- MDPI
- Published
- 2020
- Language
- EN
- Category
- nonfiction
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