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Can I read Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT) on EtoBox?
Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT) by Junaid Kashir; Ayesha Rahman Ambia; Areez Shafqat; Muhammad Raihan Sajid; Khaled AlKattan; Ahmed Yaqinuddin is a Immunology and Microbiology article available to read on EtoBox.
What is Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT) about?
## Abstract Following on from the devastating spread of COVID-19, a major global priority has been the production, procurement, and distribution of effective vaccines to ensure that the global pandemic reaches an end. However, concerns were raised about worrying side effects, particularly the occurrence of thrombosis and thrombocytopenia after administration of the Oxford/AstraZeneca and Johnson & Johnson's Janssen COVID-19 vaccine, in a phenomenon being termed vaccine-induced thrombotic thrombocytopenia (VITT). Similar to heparin-induced thrombocytopenia (HIT), this condition has been associated with the development of anti-platelet factor 4 antibodies, purportedly leading to neutrophil-platelet aggregate formation. Although thrombosis has also been a common association with COVID-19, the precise molecular mechanisms governing its occurrence are yet to be established. Recently, increasing evidence highlights the NLRP3 (NOD-like, leucine-rich repeat domains, and pyrin domain-containing protein) inflammasome complex along with IL-1β and effete neutrophils producing neutrophil extracellular traps (NETs) through NETosis. Herein, we propose and discuss that perhaps the incidence of VIT
Who reads Scientific premise for the involvement of neutrophil extracellular traps (NETs) in vaccine-induced thrombotic thrombocytopenia (VITT)?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Junaid Kashir; Ayesha Rahman Ambia; Areez Shafqat; Muhammad Raihan Sajid; Khaled AlKattan; Ahmed Yaqinuddin
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)