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Can I read The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat on EtoBox?
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat by Peter W. Stacpoole; Charles E. McCall is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat about?
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi-component megacomplexes provide a crucial mechanistic link between cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. As a consequence, PDCs also influence the metabolism of branched chain amino acids, lipids and, ultimately, oxidative phosphorylation (OXPHOS). PDC activity is an essential determinant of the metabolic and bioenergetic flexibility of metazoan organisms in adapting to changes in development, nutrient availability and various stresses that challenge maintenance of homeostasis. This canonical role of the PDC has been extensively probed over the past decades by multidisciplinary investigations into its causal association with diverse physiological and pathological conditions, the latter making the PDC an increasingly viable therapeutic target. Here we review the biology of the remarkable PDC and its emerging importance in the pathobiology and treatment of diverse congenital and acquired disorders of metabolic integration.
Who reads The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Peter W. Stacpoole; Charles E. McCall
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)