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Control of Pathogenic Bacteria Using Marine Actinobacterial Extract with Antiquorum Sensing and Antibiofilm Activity by Marco Wijaya; Dea Delicia; Diana Elizabeth Waturangi is a Medicine article available to read on EtoBox.

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## Objective The objectives of this research were to screen the anti-quorum sensing and antibiofilm activity of marine actinobacteria, isolated from several aquatic environments in Indonesia against several pathogenic bacteria, such as __Staphylococcus aureus__, __Bacillus cereus__, __Enterococcus faecalis__, __Vibrio cholerae__, __Salmonella__ Typhimurium, and __Pseudomonas aeruginosa.__ ## Results Ten out of 40 actinobacteria were found to have anti-quorum sensing activity against wild-type __Chromobacterium violaceum__ (ATCC 12472); however, the validation assay showed that only eight of 10 significantly inhibited the quorum sensing system of __Chromobacterium violaceum__ CV026. The crude actinobacteria extracts inhibited and disrupted biofilm formation produced by pathogens. The highest antibiofilm inhibition was discovered in isolates 11AC (90%), 1AC (90%), CW17 (84%), TB12 (94%), 20PM (85%), CW01 (93%) against __Staphylococcus aureus__, __Bacillus cereus__, __Enterococcus faecalis__, __Vibrio cholerae__, __Salmonella__ Typhimurium, and __Pseudomonas aeruginosa__, respectively. The highest biofilm destruction activity was observed for isolate 1AC (77%), 20PM (85%), 16PM (72%),

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Author

Marco Wijaya; Dea Delicia; Diana Elizabeth Waturangi

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)