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Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis by Lagopati, Nefeli (author);Belogiannis, Konstantinos (author);Angelopoulou, Andriani (author);Papaspyropoulos, Angelos (author);Gorgoulis, Vassilis (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis about?
P14ARF (ARF; Alternative Reading Frame) is an extensively characterized tumor suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis via p53-dependent and independent routes. ARF has been shown to be frequently lost through CpG island promoter methylation in a wide spectrum of human malignancies, such as colorectal, prostate, breast, and gastric cancers, while point mutations and deletions in the p14ARF locus have been linked with various forms of melanomas and glioblastomas. Although ARF has been mostly studied in the context of tumorigenesis, it has been also implicated in purely developmental processes, such as spermatogenesis, and mammary gland and ocular development, while it has been additionally involved in the regulation of angiogenesis. Moreover, ARF has been found to hold important roles in stem cell self-renewal and differentiation. As is often the case with tumor suppressors, ARF functions as a pleiotropic protein regulating a number of different mechanisms at the crossroad of development and tumorigenesis. Here, we provide an overview of the non-canonical functions of ARF in cancer and developmental biology, by dissecting the cross
Who reads Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lagopati, Nefeli (author);Belogiannis, Konstantinos (author);Angelopoulou, Andriani (author);Papaspyropoulos, Angelos (author);Gorgoulis, Vassilis (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)