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Longitudinal Fecal Microbiome and Metabolite Data Demonstrate Rapid Shifts and Subsequent Stabilization After an Abrupt Dietary Change in Healthy Adult Dogs by Ching-Yen Lin; Aashish R. Jha; Patrícia M. Oba; Sofia M. Yotis; Justin Shmalberg; Ryan W. Honaker; Kelly S. Swanson is a scholarly article available to read on EtoBox.

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## Abstract ## Background Diet has a large influence on gut microbiota diversity and function. Although previous studies have investigated the effect of dietary interventions on the gut microbiome, longitudinal changes in the gut microbiome, microbial functions, and metabolite profiles post dietary interventions have been underexplored. How long these outcomes require to reach a steady-state, how they relate to one another, and their impact on host physiological changes are largely unknown. To address these unknowns, we collected longitudinal fecal samples following an abrupt dietary change in healthy adult beagles (n = 12, age: 5.16 ± 0.87 year, BW: 13.37 ± 0.68 kg) using a crossover design. All dogs were fed a kibble diet (control) from d1-14, and then fed that same diet supplemented with fiber (HFD) or a protein-rich canned diet (CD) from d15-27. Fresh fecal samples were collected on d13, 16, 20, 24, and 27 for metabolite and microbiome assessment. Fecal microbial diversity and composition, metabolite profiles, and microbial functions dramatically diverged and stabilized within a few days (2 d for metabolites; 6 d for microbiota) after dietary interventions. Fecal acetate, propi

Author

Ching-Yen Lin; Aashish R. Jha; Patrícia M. Oba; Sofia M. Yotis; Justin Shmalberg; Ryan W. Honaker; Kelly S. Swanson

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN