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Can I read tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments on EtoBox?
tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments by Ben Wang; Qinglong Wang; Kai Fung Chan; Zhipeng Ning; Qianqian Wang; Fengtong Ji; Haojin Yang; Shuai Jiang; Zifeng Zhang; Bonaventure Yiu Ming Ip; Ho Ko; Jacqueline Pui Wah Chung; Ming Qiu; Jianguo Han; Philip Wai Yan Chiu; Joseph Jao Yiu Sung; Shiwei Du; Thomas Wai Hong Leung; Simon Chun Ho Yu; Li Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments about?
Micro/nanorobots provide a promising approach for intravascular therapy with high precision. However, blood vessel is a highly complex system, and performing interventional therapy in those submillimeter segments remains challenging. While micro/nanorobots can enter submillimeter segments, they may still comprise nonbiodegradable parts, posing a considerable challenge for post-use removal. Here, we developed a retrievable magnetic colloidal microswarm, composed of tPA-anchored Fe~3~O~4~@mSiO~2~ nanorobots (tPA-nbots), to archive tPA-mediated thrombolysis under balloon catheter-assisted magnetic actuation with x-ray fluoroscopy imaging system (CMAFIS). By deploying tPA-nbot transcatheter to the vicinity of the thrombus, the tPA-nbot microswarms were magnetically actuated to the blood clot at the submillimeter vessels with high precision. After thrombolysis, the tPA-nbots can be retrieved via the CMAFIS, as demonstrated in ex vivo organ of human placenta and in vivo carotid artery of rabbit. The proposed colloidal microswarm provides a promising robotic tool with high spatial precision for enhanced thrombolysis with low side effects.
Who reads tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ben Wang; Qinglong Wang; Kai Fung Chan; Zhipeng Ning; Qianqian Wang; Fengtong Ji; Haojin Yang; Shuai Jiang; Zifeng Zhang; Bonaventure Yiu Ming Ip; Ho Ko; Jacqueline Pui Wah Chung; Ming Qiu; Jianguo Han; Philip Wai Yan Chiu; Joseph Jao Yiu Sung; Shiwei Du; Thomas Wai Hong Leung; Simon Chun Ho Yu; Li Zhang
- Publisher
- American Association for the Advancement of Science
- Published
- 2024
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)