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Retrospective Analysis of Immunosuppressive and Anti‐thrombotic Protocols in Nonassociative Immune Mediated Hemolytic Anemia in Dogs by Jennifer Weng; Nyssa A. Levy; Haley Y. Abbott; Jose A. Mix; Robert W. Wills; Andrew J. Mackin; John M. Thomason; Harry Cridge is a Medicine article available to read on EtoBox.
What is Retrospective Analysis of Immunosuppressive and Anti‐thrombotic Protocols in Nonassociative Immune Mediated Hemolytic Anemia in Dogs about?
## Abstract ## Background Evidence supporting the effectiveness of therapeutic protocols for nonassociative immune‐mediated hemolytic anemia (na‐IMHA) is weak. ## Hypothesis/Objectives Investigate the efficacy of various drugs in na‐IMHA. ## Animals Two hundred forty‐two dogs. ## Methods Multi‐institutional retrospective study (2015‐2020). Immunosuppressive effectiveness was determined by time to packed cell volume (PCV) stabilization and duration of hospitalization through analysis by mixed model linear regression. Occurrence of disease relapse, death, and antithrombotic effectiveness, were analyzed using mixed model logistic regression. ## Results Use of corticosteroids vs a multi‐agent protocol had no effect on time to PCV stabilization (__P__ = .55), duration of hospitalization (__P__ = .13), or case fatality (__P__ = .06). A higher rate of relapse (__P__ = .04; odds ratio: 3.97; 95% confidence interval [CI]: 1.06‐14.8) was detected in dogs receiving corticosteroids (11.3%) during follow‐up (median: 28.5 days, range: 0‐1631 days) compared to multiple agents (3.1%) during follow up (median: 47.0 days, range: 0‐1992 days). When comparing drug protocols, there was no effect on tim
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- Author
- Jennifer Weng; Nyssa A. Levy; Haley Y. Abbott; Jose A. Mix; Robert W. Wills; Andrew J. Mackin; John M. Thomason; Harry Cridge
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)