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Can I read Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography on EtoBox?
Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography by Janusz Żukowski; Danuta Sybilska; Jacek Bojarski is a Chemistry article available to read on EtoBox.
What is Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography about?
Using LiChrosorb RP-18 as the stationary phase, systematic studies were performed on the changes in the capacity factors of a series of hydantoin and barbituric acid derivatives (including some therapeutically useful drugs) with variation in the concentrations of 01-and /?-cyclodextrin and heptakis(2&-di-O-methyl)+cyclodextrin in the mobile phase.It has been found that both /?-cyclodextrin and its dimethyl derivative exhibit enantioselectivities towards hydantoins and barbiturates that contain a chiral carbon atom in the heterocyclic ring. No selectivity was observed with a-cyclodextrin. Owing to the strong adsorption of dimethylated /3-cyclodextrin from its dilute solutions on an ODS surface, a new mechanism for the separation of enantiomeric barbiturates was established.
Who reads Application of α- and β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin as mobile phase components for the separation of some chiral barbiturates into enantiomers by reversed-phase high-performance liquid chromatography?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Janusz Żukowski; Danuta Sybilska; Jacek Bojarski
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 1986
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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