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Section 4: Clinical Pharmacy Services - 4CPS-004 Evaluation of the use of hydrocortisone, vitamin C and thiamine for the treatment of septic shock by Martín Cerezuela, M; Sancho Ferrando, E; Beltran Garcia, I; Centelles Oria, M; Villarreal Tello, E; Gordon Sahuquillo, M; Castellanos Ortega, A; Ramirez Galleymore, P; Poveda Andres, JL is a scholarly article available to read on EtoBox.

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methods Data on faecal output, March 2018 to September 2019, were collected for patients with SBS-IF and a high faecal output, despite treatment with antimotility and antisecretory drugs, who received liraglutide to reduce ostomy output. Results Ten patients received liraglutide at a standard dose. Small bowel length was <140 cm. Pretreatment faecal output was 3230 mL/day. Two patients did not respond to treatment, while the remaining eight patients (80%) achieved a post-treatment faecal output of 1983 mL/day, with an average reduction of 1402 mL/day (-43%) after 8 weeks of therapy. One patient discontinued therapy following intestinal recanalisation, while therapy is ongoing in seven patients. Liraglutide was well tolerated and all patients reported an improvement in quality of life. Conclusion and relevance Liraglutide seems to have a place in the limited treatment armamentarium available for patients with SBS-IF, who have a significantly impaired quality of life. ## REFERENCES AND/OR ACKNOWLEDGEMENTS 1. Hvistendahl M, et al. Effect of liraglutide treatment on jejunostomy output in patients with short bowel syndrome: an open-label pilot study.

Author

Martín Cerezuela, M; Sancho Ferrando, E; Beltran Garcia, I; Centelles Oria, M; Villarreal Tello, E; Gordon Sahuquillo, M; Castellanos Ortega, A; Ramirez Galleymore, P; Poveda Andres, JL

Publisher

British Medical Journal Publishing Group

Published

2020

Language

EN