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What is Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction Through Activating The Nrf2 HO-1 Pathway in Intervertebral Disc Degeneration about?

This research article investigates the protective effects of Dimethyl Fumarate (DMF) on nucleus pulposus cells (NPCs) against intervertebral disc degeneration (IVDD) induced by lipopolysaccharides (LPS). The study demonstrates that DMF activates the Nrf2/HO-1 signaling pathway, reducing oxidative stress, inflammation, and apoptosis in NPCs. These findings suggest that DMF may offer a novel pharmacological treatment strategy for IVDD.

Author

p13abhishekv

Language

EN