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The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis by Jiehua Chen; Yu Deng; Jing Zhao; Zhengxiu Luo; Wansheng Peng; Juan Yang; Luo Ren; Lijia Wang; Zhou Fu; Xiqiang Yang; Enmei Liu is a Immunology and Microbiology article available to read on EtoBox.
What is The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis about?
Objective Interleukin (IL)-17 plays an important role in the pathogenesis of asthma. We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 (rs2275913, IL-17 G-152A) and asthma-related traits. Its effect on IL-17 production was also attractive. Methods One hundred and sixty eight childhood asthmatic patients, 144 bronchiolitis patients, and 205 healthy controls were recruited in this study. SNP rs2275913 was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Peripheral blood mononuclear cells (PBMCs) from parts of healthy controls with different genotype were isolated and cultured with phytohaemagglutinin (PHA) for detection of IL-17 in the supernatants. Results SNP rs2275913 was associated with asthma (P= 0.03) in genotype frequency test. Children with homozygous A were 2.29 times more likely to have asthma than others (95% confidence interval 1.39-3.78, P=0.001). The strength of associations was moderately higher by allergy comorbidity. Furthermore, SNP rs2275913 A allele was associated with abnormal lung function and serum total IgE in asthmatics, although the production of IL-17 by PHAinduced PBMC seemed to be not dif
Who reads The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jiehua Chen; Yu Deng; Jing Zhao; Zhengxiu Luo; Wansheng Peng; Juan Yang; Luo Ren; Lijia Wang; Zhou Fu; Xiqiang Yang; Enmei Liu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2010
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)