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Aptamer-mediated hollow MnO~2~ for targeting the delivery of sorafenib by Ziyue Wang; Cuicui Wu; Jinren Liu; Shunxin Hu; Junli Yu; Qiangqiamg Yin; Hongda Tian; Zhipeng Ding; Guiqiang Qi; Li Wang; Liguo Hao is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Aptamer-mediated hollow MnO~2~ for targeting the delivery of sorafenib about?

Sorafenib (SRF) presents undesirable effects in clinical treatment, due to the lack of targeting, poor water solubility, and obvious side effects. In this study, we constructed a novel nanodrug carrier system for accurate and efficient delivery of SRF, improving its therapeutic effects and achieving tumor-specific imaging. The hollow mesoporous MnO 2 (H-MnO 2 ) nanoparticles equipped with target substance aptamers (APT) on the surface were used to load SRF for the first time.The resulting H-MnO 2 -SRF-APT could specifically bound to glypican-3 (GPC3) receptors on the surface of hepatocellular carcinoma (HCC), rapidly undergoing subsequent degradation under decreased pH conditions in the tumor microenvironment (TME) and releasing the loaded SRF. In this process, Mn 2+ ions were used for T 1 -weighted magnetic resonance imaging simultaneously. The in vitro cell experiments indicated that H-MnO 2 -SRF-APT showed much more effects on the inhibition in the proliferation of Huh7 and HepG2 HCC cells than that of the non-targeted H-MnO 2 -SRF and free SRF. Besides, the in vivo results further confirmed that H-MnO 2 -SRF-APT could effectively inhibit the growth of xenograft tumors Huh7 in t

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Author

Ziyue Wang; Cuicui Wu; Jinren Liu; Shunxin Hu; Junli Yu; Qiangqiamg Yin; Hongda Tian; Zhipeng Ding; Guiqiang Qi; Li Wang; Liguo Hao

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)