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Maternal Vasoactive Exposures, Amniotic Bands, and Terminal Transverse Limb Defects by Martha M. Werler; Jaclyn L. F. Bosco; Stuart K. Shapira is a Medicine article available to read on EtoBox.

What is Maternal Vasoactive Exposures, Amniotic Bands, and Terminal Transverse Limb Defects about?

## Abstract **BACKGROUND:** Limb reduction deficiencies that are accompanied by amniotic bands (AB‐Ls) and terminal transverse limb deficiencies (TLDs) have each been attributed to vascular disruption; for the former, however, it is not clear if amniotic bands are the primary cause of or are secondary to vascular disruption. If amniotic bands are secondary to vascular disruption, then a shared pathogenesis for each case group might be exhibited by similar risk factors. **METHODS:** We evaluated maternal age, education, race/ethnicity, parity, pregnancy wantedness, and vasoactive exposures among 139 AB‐L and 373 TLD cases, using interview data collected from mothers in 10 states by the National Birth Defects Prevention Study. Vasoactive exposures included maternal cigarette smoking and use of decongestants, nonsteroid anti‐inflammatory drugs, and antihypertensive drugs in the periconceptional period. **RESULTS:** Increased risk estimates were observed for Black mothers (OR 2.5; 95% CI: 1.5–4.1) and nulliparous mothers (2.1; 1.4–3.0) in relation to AB‐L, while neither was associated with TLD. Hispanic women (1.4; 1.0–1.9) and those not wanting the pregnancy (1.5; 1.1–2.1) had increas

Who reads Maternal Vasoactive Exposures, Amniotic Bands, and Terminal Transverse Limb Defects?

Author

Martha M. Werler; Jaclyn L. F. Bosco; Stuart K. Shapira

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-0752)

Published

2008

Language

EN

Field

Medicine (Health Sciences)