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Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture by Bernard Refouvelet; Catherine Guyon; Yves Jacquot; Corinne Girard; Hervé Fein; Françoise Bévalot; Jean-François Robert; Bruno Heyd; Georges Mantion; Lysiane Richert; Alain Xicluna is a Chemistry article available to read on EtoBox.
What is Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture about?
We report here the synthesis of aromatic coumarins and aromatic a-quinolones which were evaluated in vitro for their protective potentialities against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage on human liver cell death, i.e., human hepatoma HepG2 cell line and human hepatocytes in primary culture. We found that the presence of a benzylidene at the 3-position or a heterocycle with N and S heteroatoms on the benzopyrone or quinolone system was essential for the protective effect of these compounds against t-BHP-induced decrease in viability of cells. We found also that a methoxy group on the aromatic ring systems decreased this potential. t-BHP-induced cytotoxicity in primary cultures of human hepatocytes could be therefore prevented by these compounds suggesting that they could display hepatoprotective effects in humans.
Who reads Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Bernard Refouvelet; Catherine Guyon; Yves Jacquot; Corinne Girard; Hervé Fein; Françoise Bévalot; Jean-François Robert; Bruno Heyd; Georges Mantion; Lysiane Richert; Alain Xicluna
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2004
- Language
- EN
- Field
- Chemistry (Physical Sciences)