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Can I read Microenvironment in Acute Myeloid Leukemia: Focus on Senescence Mechanisms, Therapeutic Interactions, and Future Directions on EtoBox?
Microenvironment in Acute Myeloid Leukemia: Focus on Senescence Mechanisms, Therapeutic Interactions, and Future Directions by Luca Guarnera; Enrico Santinelli; Elisa Galossi; Antonio Cristiano; Emiliano Fabiani; Giulia Falconi; Maria Teresa Voso is a Medicine article available to read on EtoBox.
What is Microenvironment in Acute Myeloid Leukemia: Focus on Senescence Mechanisms, Therapeutic Interactions, and Future Directions about?
Acute myeloid leukemia (AML) is a disease with a dismal prognosis, mainly affecting the elderly. In recent years, new drugs have improved life expectancy and quality of life, and a better understanding of the genetic-molecular nature of the disease has shed light on previously unknown aspects of leukemogenesis. In parallel, increasing attention has been attracted to the complex interactions between cells and soluble factors in the bone marrow (BM) environment, collectively known as the microenvironment. In this review, we discuss the central role of the microenvironment in physiologic and pathologic hematopoiesis and the mechanisms of senescence, considered a fundamental protective mechanism against the proliferation of damaged and pretumoral cells. The microenvironment also represents a fertile ground for the development of myeloid malignancies, and the leukemic niche significantly interacts with drugs commonly used in AML treatment. Finally, we focus on the role of the microenvironment in the engraftment and complications of allogeneic hematopoietic stem cell transplantation, the only curative option in a conspicuous proportion of patients.
Who reads Microenvironment in Acute Myeloid Leukemia: Focus on Senescence Mechanisms, Therapeutic Interactions, and Future Directions?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Luca Guarnera; Enrico Santinelli; Elisa Galossi; Antonio Cristiano; Emiliano Fabiani; Giulia Falconi; Maria Teresa Voso
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)