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Comparison of virulence factors of oral Candida dubliniensis and Candida albicans isolates in healthy people and patients with chronic candidosis by J. Hannula; M. Saarela; B. Dogan; J. Paatsama; P. Koukila-Kähkölä; S. Pirinen; H.-L. Alakomi; J. Perheentupa; S. Asikainen is a Dentistry article available to read on EtoBox.
What is Comparison of virulence factors of oral Candida dubliniensis and Candida albicans isolates in healthy people and patients with chronic candidosis about?
We determined differences in the expression of certain virulence factors between oral __Candida dubliniensis__ and __Candida albicans__ species. In addition, clonal differences were sought among __C. albicans__ isolates recovered from patients with and without compromised immune system. The material comprised 93 clinical yeast isolates originated in 40 subjects (1–5 isolates per subject). All 26 __C. dubliniensis__ isolates and 46 __C. albicans__ isolates originated from healthy routine dental clinic patients. Additionally, 21 __C. albicans__ isolates were collected from patients with autoimmune polyendocrinopathy–candidosis–ectodermal dystrophy (APECED), who have chronic candidosis as one manifestation of their immunocompromising disease. Polymerase chain reaction amplification using the random sequence primer OPE‐03 enabled grouping of the __C. dubliniensis__ isolates in 2 genotypes (I and II) and __C. albicans__ isolates in 15 genotypes (I–XV). No significant difference was found in the distribution of genotypes between the patients with APECED and the healthy subjects. __C. dubliniensis__ isolates exhibited high‐frequency phenotypic switching significantly more frequently than
Who reads Comparison of virulence factors of oral Candida dubliniensis and Candida albicans isolates in healthy people and patients with chronic candidosis?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- J. Hannula; M. Saarela; B. Dogan; J. Paatsama; P. Koukila-Kähkölä; S. Pirinen; H.-L. Alakomi; J. Perheentupa; S. Asikainen
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0055)
- Published
- 2000
- Language
- EN
- Field
- Dentistry (Health Sciences)