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Hybrid Theranostic Cubosomes for Efficient NIR-Induced Photodynamic Therapy by Urszula Bazylińska; Dominika Wawrzyńczyk; Julita Kulbacka; Giacomo Picci; Livia Salvati Manni; Stephan Handschin; Marco Fornasier; Claudia Caltagirone; Raffaele Mezzenga; Sergio Murgia is a Engineering article available to read on EtoBox.
What is Hybrid Theranostic Cubosomes for Efficient NIR-Induced Photodynamic Therapy about?
In recent years, lipid bicontinuous cubic liquid-crystalline nanoparticles known as cubosomes have been under investigation because of their favorable properties as drug nanocarriers useful for anticancer treatments. Herein, we present organic/inorganic hybrid, theranostic cubosomes stabilized in water with a shell of alternate layers of chitosan, single strand DNA (model genetic material for potential gene therapy), and folic acid–chitosan conjugate (the outmost layer), coencapsulating up-converting Er^3+^ and Yb^3+^ codoped NaYF~4~ nanoparticles and daunorubicin. The latter acts as a chemotherapeutic drug of photosensitizing activity, while up-converting nanoparticles serve as energy harvester and diagnostic agent. Cellular uptake and NIR-induced photodynamic therapy were evaluated __in vitro__ against human skin melanoma (MeWo) and ovarian (SKOV-3) cancer cells. Results evidenced the preferential uptake of the theranostic cubosomes in SKOV-3 cells in comparison to uptake in MeWo cells, and this effect was enhanced by the folic acid functionalization of the cubosomes surface. Nanocarriers coloaded with the hybrid fluorophores exhibited a superior NIR-induced photodynamic activity
Who reads Hybrid Theranostic Cubosomes for Efficient NIR-Induced Photodynamic Therapy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Urszula Bazylińska; Dominika Wawrzyńczyk; Julita Kulbacka; Giacomo Picci; Livia Salvati Manni; Stephan Handschin; Marco Fornasier; Claudia Caltagirone; Raffaele Mezzenga; Sergio Murgia
- Publisher
- American Chemical Society (ACS)
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)