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Modelling and Diagnostics of Batch Processes and Analogous Kinetic Experiments by Svante Wold; Nouna Kettaneh; Håkan Fridén; Andrea Holmberg is a Chemistry article available to read on EtoBox.

What is Modelling and Diagnostics of Batch Processes and Analogous Kinetic Experiments about?

In chemical kinetics and batch processes K variables are measured on the batches at regular time intervals. This gives a Ž . J = K matrix for each batch J time points times K variables . Consequently, a set of N normal batches gives a three-way Ž . matrix of dimension N = J = K . The case when batches have different length is also discussed. In a typical industrial application of batch modelling, the purpose is to diagnose an evolving batch as normal or not, and to obtain indications of variables that together behave abnormally in batch process upsets. Other applications giving the same form of data include Ž . pharmaco-kinetics, clinical and pharmacological trials where patients or mice are followed over time, material stability testing and other kinetic investigations. A new approach to the multivariate modelling of three-way kinetic and batch process ŽŽ . . ŽŽ . data is presented. This approach is based on an initial PLS analysis of the N = J = K unfolded matrix batch = time = . variables with 'local time' used as a single y-variable. This is followed by a simple statistical analysis of the resulting scores and results in multivariate control charts suitable for monitoring the k

Who reads Modelling and Diagnostics of Batch Processes and Analogous Kinetic Experiments?

Author

Svante Wold; Nouna Kettaneh; Håkan Fridén; Andrea Holmberg

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0169-7439)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)